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KMID : 0380020100250010097
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Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 1 p.97 ~ p.102
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Preparation of Thiol-chitosan Coated EPA-containing Liposome and Immune Response in Mouse Model of Atopic Dermatitis
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Jung Hyo-Yun
Kim JIn
Lee Yong-Wook
Lee Ki-Young
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Abstract
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The enhancement of immunity for atopic dermatitis with application of eicosapentaenoic acid (EPA)-loaded liposome was evaluated on NC/Nga mice. The EPA-loaded liposome was coated with thiol-chitosan. The liposomes were characterized with transmission electron microscopy (TEM), surface zeta potential & particle size analyzer (Zeta-PSA) and differential scanning calorimetry (DSC). The loading efficiency of EPA in the liposome was about 4.7%. The particle size of the EPA-Ioaded liposome was about 230 nm. The values of Immunoglobulin E (IgE), interleukin-4 (IL-4), and tumor necrosis factor- (TNF-) were reduced significantly with application of the EPA-loaded liposome. The interferon- (IFN-) value was increased with the application effect. It is concluded that EPA loaded liposome have immunity advancing effects in mouse model of atopic dermatitis.
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KEYWORD
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EPA, Atopic dermatitis, Immunity, IgE, IL-4, TNF-, IFN-
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